$\begin{array}{l}\text{Here,\hspace{0.17em}}\\ \Rightarrow \text{\hspace{0.17em}350\% of ?}÷\text{50 + 248 = 591}\\ \\ \text{It can also be written as}\\ \\ \Rightarrow \frac{350}{100}\times ?÷50+248=591\\ \\ \text{By putting x at the place of ?}\\ \\ \Rightarrow \text{\hspace{0.17em}\hspace{0.17em}3.5}\times x÷\text{50 + 248 = 591}\\ \\ \Rightarrow \frac{3.5x}{50}+248=591\\ \\ \Rightarrow \frac{3.5x}{50}=591-248=343\\ \\ \Rightarrow \text{3.5}x\text{ = 343}\times \text{50}\\ \\ \Rightarrow \text{x=}\frac{343\times 50}{3.5}=98\times 50=4900\end{array}$

Hence, Option E is correct.